Nakhon Phanom Highway District was established in B.E. 2498 (1955) under the Ubon Ratchathani Highway District, Maintenance Division, Department of Highways. Mr. Somporn Saikasem served as the first District Director.

Later, in B.E. 2530 (1987), the Department of Highways reorganized the highway jurisdiction areas and established the Sakon Nakhon Highway District, which is currently known as Highway Office No. 3 (Sakon Nakhon), Bureau of Highway Maintenance, Department of Highways. Since its establishment to the present, the office has undergone organizational changes and is now named Nakhon Phanom Highway District.

Address: 77 Chayangkun Road, Nai Mueang Subdistrict, Mueang District, Nakhon Phanom 48000. Land Plot No. NP.169, covering an area of 19-0-66 rai.